Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08POF
|
||||
| Former ID |
DCL000036
|
||||
| Drug Name |
ALX-0081
|
||||
| Indication | Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0] | Phase 2 | [532188] | ||
| Company |
Ablynx
|
||||
| Target and Pathway | |||||
| Target(s) | Von Willebrand factor | Target Info | Binder | [550615] | |
| Reactome | Platelet degranulation | ||||
| Intrinsic Pathway of Fibrin Clot Formation | |||||
| Integrin cell surface interactions | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| GP1b-IX-V activation signalling | |||||
| MAP2K and MAPK activation | |||||
| Platelet Adhesion to exposed collagen | |||||
| References | |||||
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