Drug General Information
Drug ID	D0V7US
Former ID	DIB006681
Drug Name	NKP 608
Synonyms	AV608)
Indication	Mood disorder [ICD10:F30-F39]		Phase 2	[531755]
Company	Novartis; Avera Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Substance-P receptor	Target Info	Antagonist	[531755]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Measles
PANTHER Pathway	CCKR signaling map ST
Reactome	G alpha (q) signalling events
WikiPathways	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 531755	Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study. Aliment Pharmacol Ther.2012 Feb;35(3):360-7.
Ref 531755	Neurokinin-1-receptor antagonism decreases anxiety and emotional arousal circuit response to noxious visceral distension in women with irritable bowel syndrome: a pilot study. Aliment Pharmacol Ther.2012 Feb;35(3):360-7.

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