Drug Information

Drug General Information
Drug ID
D01FLR
Former ID
DIB008071
Drug Name
Vanilloid VR1 receptor antagonists
Synonyms
Vanilloid VR1 receptor antagonists (urinary incontinence); Vanilloid VR1 receptor antagonists (urinary incontinence), Bayer
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Investigative [552156]
Company
Bayer Yakuhin Ltd
Structure
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2D MOL

3D MOL
Canonical SMILES
c1(C(F)(F)F)c(ccc(NC(=O)Nc2c3c(c(cc2Cl)Cl)ccc(c3)O)c1)C<br />l
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Antagonist [543861]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 552156WO patent application no. 2000050387A1, Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof.
Ref 543861(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 507).

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