Drug Information

Drug General Information
Drug ID
D0H5TU
Former ID
DIB004048
Drug Name
RQ-00000008
Synonyms
CJ-042794; Prostaglandin EP4 antagonists (chronic inflammatory pain), Pfizer; Prostaglandin EP4 antagonists (chronic inflammatory pain), RaQualia
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [541166]
Company
Pfizer Inc
Structure
Download
2D MOL

3D MOL
Formula
C22H17ClFNO4
InChI
InChI=1S/C22H17ClFNO4/c1-13(14-2-4-15(5-3-14)22(27)28)25-21(26)19-12-16(23)6-11-20(19)29-18-9-7-17(24)8-10-18/h2-13H,1H3,(H,25,26)(H,27,28)/t13-/m0/s1
InChIKey
MWBNCZHVEXULBD-ZDUSSCGKSA-N
PubChem Compound ID
11524454
PubChem Substance ID
16626432, 23651265, 78750887, 103723070, 136959906, 139751608, 160829456, 162114805, 163093991, 163395060, 163843890, 170559094, 178102481, 184816679, 189659034, 203094313, 204429762, 223619652, 223933360, 226984835, 249047727, 252475190
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Antagonist [543780]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541166(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5857).
Ref 543780(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343).

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