Drug Information

Drug General Information
Drug ID
D0K4VN
Former ID
DIB011127
Drug Name
Molecule 21
Synonyms
EP3 antagonists (pain/ uterine disease), Ono Pharmaceutical; Prostaglandin-E receptor 3 antagonists (pain/ uterine disease); Prostaglandin-E receptor 3 antagonists (pain/ uterine disease), Ono Pharmaceutical
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Investigative [543779]
Company
Ono Pharmaceutical Co Ltd
Structure
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2D MOL

3D MOL
Canonical SMILES
[C@@H](NC(=O)c1c(CCC(=O)O)ccc(c1)COc1cc(ccc1C)F)(CC(C)C<br />)c1cc(cc(c1)C)C
Target and Pathway
Target(s) Prostaglandin E2 receptor EP3 subtype Target Info Antagonist [543779]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Regulation of lipolysis in adipocytes
Pathways in cancer
NetPath Pathway IL2 Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543779(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 342).
Ref 543779(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 342).

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