Drug Information

Drug General Information
Drug ID
D02CCA
Former ID
DIB006564
Drug Name
GSK-172981
Synonyms
GSK-172981; GSK-256471; SB-218795; SB-235375; SB-244487; SB-400238; SB-414240; SK-797230; NK-2 antagonists, GSK; NK-3 antagonists, GlaxoSmithKline; NK-3 antagonists, SB
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Investigative [541097]
Company
SmithKline Beecham SpA
Structure
Download
2D MOL

3D MOL
Formula
C29H29N3O3S
InChI
InChI=1S/C29H29N3O3S/c1-32(36(2,34)35)19-24-26(29(33)31-27(22-17-18-22)20-11-5-3-6-12-20)23-15-9-10-16-25(23)30-28(24)21-13-7-4-8-14-21/h3-16,22,27H,17-19H2,1-2H3,(H,31,33)/t27-/m1/s1
InChIKey
YTXUTYGRBYCUIL-HHHXNRCGSA-N
CAS Number
CAS 174635-53-1
PubChem Compound ID
44570980
PubChem Substance ID
103609375, 163361966, 172650757, 178102399, 198937461
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Antagonist [543793]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541097(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5774).
Ref 543793(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 362).

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