Drug General Information
Drug ID	D06UUP
Former ID	DIB001331
Drug Name	NK-3 antagonists
Synonyms	NK-3 antagonists (CNS diseases); NK-3 antagonists (CNS diseases), Lundbeck
Indication	Central nervous system disease [ICD10:G00-G99]		Investigative	[552073]
Company	H Lundbeck A/S
Structure		Download 2D MOL 3D MOL
Canonical SMILES	S(=O)(=O)(N(C)C)N1CCN(C[C@H]2[C@](c3ccc(c(c3)Cl)Cl)(C2)<br />C(=O)N(C)Cc2ccc(cc2)F)CC1
Target and Pathway
Target(s)	Nigral tachykinin NK(3) receptor	Target Info	Antagonist	[543793]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 552073	Novel NK(3) receptor antagonists for the treatment of schizophrenia and other CNS indications. Curr Opin Drug Discov Devel. 2010 Jul;13(4):379-88.
Ref 543793	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 362).

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