Drug Information

Drug General Information
Drug ID
D0NW2B
Former ID
DIB010242
Drug Name
NK3 antagonist PET ligand
Synonyms
NK3 antagonist PET ligand (psychiatric disease); NK3 antagonist PET ligand (psychiatric disease), AstraZeneca
Indication Psychiatric disorder [ICD9: 290-319; ICD10:F01-F99] Investigative [543793]
Company
AstraZeneca plc
Structure
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2D MOL

3D MOL
Canonical SMILES
c1ccc2c(c1)c(c(c(n2)c1ccccc1)[S@@](=O)C)C(=O)N[C@H](c1c<br />cccc1)CC
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Antagonist [543793]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543793(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 362).
Ref 543793(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 362).

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