Drug General Information
Drug ID	D04USG
Former ID	DIB007951
Drug Name	MMP-13 inhibitors
Synonyms	MMP-13 inhibitors (arthritis); MMP-13 inhibitors (arthritis), Boehringer-Ingelheim
Indication	Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47]		Investigative	[552075]
Company	Boehringer Ingelheim Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1nccc(c1)CNC(=O)c1nc(c([nH]1)c1ccc2c(c1)cc([nH]2)c1nc(<br />no1)C)C
Target and Pathway
Target(s)	Collagenase 3	Target Info	Inhibitor	[528284], [536172]
NetPath Pathway	IL1 Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structures
WikiPathways	Endochondral Ossification
	Activation of Matrix Metalloproteinases
	Oncostatin M Signaling Pathway
	AGE/RAGE pathway
	Matrix Metalloproteinases
References
Ref 552075	SAR studies of non-zinc-chelating MMP-13 inhibitors: improving selectivity and metabolic stability. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5039-43
Ref 528284	Effects of selective matrix metalloproteinase inhibitor (PG-116800) to prevent ventricular remodeling after myocardial infarction: results of the PREMIER (Prevention of Myocardial Infarction Early Remodeling) trial. J Am Coll Cardiol. 2006 Jul 4;48(1):15-20. Epub 2006 Jun 21.
Ref 536172	Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7. Epub 2006 Jan 20.

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