Drug General Information
Drug ID	D0T1DZ
Former ID	DIB004027
Drug Name	EPI-001
Drug Type	Small molecular drug
Indication	Prostate cancer [ICD9: 185; ICD10:C61]		Investigative	[525416]
Company	British Columbia Cancer Agency
Structure		Download 2D MOL 3D MOL
Formula	C21H27ClO5
Canonical SMILES	CC(C)(c1ccc(cc1)OCC(CCl)O)c1ccc(cc1)OCC(CO)O
PubChem Compound ID	4166922
Target and Pathway
Target(s)	Androgen receptor	Target Info	Modulator	[525416]
KEGG Pathway	Oocyte meiosis
	Pathways in cancer
	Prostate cancer
NetPath Pathway	EGFR1 Signaling Pathway
	AndrogenReceptor Signaling Pathway
	FSH Signaling Pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Coregulation of Androgen receptor activity
	Regulation of Androgen receptor activity
	Nongenotropic Androgen signaling
	Regulation of nuclear beta catenin signaling and target gene transcription
	FOXA1 transcription factor network
	Notch-mediated HES/HEY network
Reactome	Nuclear Receptor transcription pathway
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways	SIDS Susceptibility Pathways
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Nuclear Receptors
	Androgen receptor signaling pathway
References
Ref 525416	EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28;6(6):3811-24.
Ref 525416	EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 2015 Feb 28;6(6):3811-24.

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