TTD | Drug: D00QHT

Drug General Information
Drug ID	D00QHT
Former ID	DIB011028
Drug Name	AK-295
Synonyms	Vasolex; AK-265; AK-275; AK-295; CX-295; Calpain inhibitors (neuropathy); Calpain inhibitors (neuropathy), AxoTect; Calpain inhibitors, Cortex/Alkermes
Drug Type	Small molecular drug
Indication	Cerebral infarction [ICD10:I63]		Terminated	[546355]
Company	Alkermes Inc
Structure		Download 2D MOL 3D MOL
Formula	C26H40N4O6
Canonical SMILES	C(=O)(C(=O)NCCCN1CCOCC1)C(NC(=O)C(NC(=O)OCc1ccccc1)CC(C<br />)C)CC
PubChem Compound ID	183798
Target and Pathway
Target(s)	Calpain	Target Info	Inhibitor	[543595]
KEGG Pathway	Protein processing in endoplasmic reticulum
	Apoptosis
	Alzheimer's disease
Reactome	Degradation of the extracellular matrix
WikiPathways	Focal Adhesion
	Integrated Pancreatic Cancer Pathway
	Alzheimers Disease
	Integrin-mediated Cell Adhesion
References
Ref 546355	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007674)
Ref 543595	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2336).

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Drug Information