Drug Information

Drug General Information
Drug ID
D0SR3T
Former ID
DIB016416
Drug Name
JN-711
Synonyms
JN-711; Alpha-7 nicotinic acetylcholine receptor agonists (CNS disorders); Alpha-7 nicotinic acetylcholine receptor agonists (CNS disorders), Novartis
Indication Central nervous system disease [ICD10:G00-G99] Investigative [543845]
Company
Novartis AG
Structure
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2D MOL

3D MOL
Canonical SMILES
c1ccc(c(c1)[C@@H]1[C@H](C1)C1N(C(=O)[C@@H](CN2CCCCC2)C1<br />)C)Cl
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Agonist [543845]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 543845(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468).
Ref 543845(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468).

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