Drug Information
Drug General Information | |||||
---|---|---|---|---|---|
Drug ID |
D06EHW
|
||||
Former ID |
DIB012323
|
||||
Drug Name |
IAI-100
|
||||
Synonyms |
ADAM inhibitors (cancer); IAI-100; IAI-102; INCB-3531; INCB-3619; A disintegrin and metalloprotease inhibitors (cancer), Incyte;ADAM inhibitors (cancer), Incyte; HER-2 sheddase inhibitors (cancer), Incyte
|
||||
Drug Type |
Small molecular drug
|
||||
Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Investigative | [543240] | ||
Company |
Incyte Corp
|
||||
Structure |
Download2D MOL |
||||
Formula |
C22H27N3O5
|
||||
InChI |
InChI=1S/C22H27N3O5/c1-30-21(28)25-14-22(9-10-22)13-17(19(26)23-29)18(25)20(27)24-11-7-16(8-12-24)15-5-3-2-4-6-15/h2-7,17-18,29H,8-14H2,1H3,(H,23,26)/t17-,18-/m0/s1
|
||||
InChIKey |
CKZHFOKQZRZCPF-ROUUACIJSA-N
|
||||
CAS Number |
CAS 791826-72-7
|
||||
PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | ADAM 10 | Target Info | Inhibitor | [543239] | |
NetPath Pathway | RANKL Signaling Pathway | ||||
PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
Reactome | Collagen degradation | ||||
Degradation of the extracellular matrix | |||||
Activated NOTCH1 Transmits Signal to the Nucleus | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 t(7 | |||||
M1580_K2555) Translocation Mutant | |||||
Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
NOTCH2 Activation and Transmission of Signal to the Nucleus | |||||
EPH-ephrin mediated repulsion of cells | |||||
References |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.