Drug General Information
Drug ID
D06EHW
Former ID
DIB012323
Drug Name
IAI-100
Synonyms
ADAM inhibitors (cancer); IAI-100; IAI-102; INCB-3531; INCB-3619; A disintegrin and metalloprotease inhibitors (cancer), Incyte;ADAM inhibitors (cancer), Incyte; HER-2 sheddase inhibitors (cancer), Incyte
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543240]
Company
Incyte Corp
Structure
Download
2D MOL

3D MOL

Formula
C22H27N3O5
InChI
InChI=1S/C22H27N3O5/c1-30-21(28)25-14-22(9-10-22)13-17(19(26)23-29)18(25)20(27)24-11-7-16(8-12-24)15-5-3-2-4-6-15/h2-7,17-18,29H,8-14H2,1H3,(H,23,26)/t17-,18-/m0/s1
InChIKey
CKZHFOKQZRZCPF-ROUUACIJSA-N
CAS Number
CAS 791826-72-7
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) ADAM 10 Target Info Inhibitor [543239]
KEGG Pathway Alzheimer's disease
Epithelial cell signaling in Helicobacter pylori infection
NetPath Pathway RANKL Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Pathway Interaction Database Notch signaling pathway
Presenilin action in Notch and Wnt signaling
Posttranslational regulation of adherens junction stability and dissassembly
Reactome Collagen degradation
Degradation of the extracellular matrix
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7
M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
WikiPathways Hypertrophy Model
Copper homeostasis
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH2
Alzheimers Disease
References
Ref 543240(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8679).
Ref 543239(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8679).

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