Drug Information

Drug General Information
Drug ID
D03HLK
Former ID
DIB001177
Drug Name
PRT-060096
Synonyms
PRT-060096; PRT-060280; PRT-060288; PRT-060289; PRT-060392; PRT-060592; PRT-060674; PRT-061105; PRT-061106; PRT-061110; PRT-061171; Non-sulfonylurea P2Y12 antagonists (cardiovascular disease); Non-sulfonylurea P2Y12 antagonists (cardiovascular disease), Portola
Indication Cardiovascular disorder [ICD10:I00-I99] Investigative [543771]
Company
Portola Pharmaceuticals Inc
Structure
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2D MOL

3D MOL
Canonical SMILES
O=S(=O)(c1ccc(s1)Cl)NC(=O)c1ccc(n2c(=O)[nH]c3cc(ccc3c2=<br />O)NCc2ccc(cc2)F)cc1
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Antagonist [543771]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 543771(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328).
Ref 543771(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328).

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