Drug General Information
Drug ID	D06CCR
Former ID	DIB007530
Drug Name	Fialuridine
Synonyms	FIAU
Drug Type	Small molecular drug
Indication	HBV infection [ICD9: 070.2-070.3; ICD10:B16, B18.0, B18.1]		Phase 2	[521412]
Company	Oclassen Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Formula	C9H10FIN2O5
Canonical SMILES	n1([C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F)c(=O)[nH]c(=O)c(c<br />1)I
CAS Number	CAS 69123-98-4
PubChem Compound ID	46781574
Target and Pathway
Target(s)	DNA polymerase	Target Info	Modulator	[534117]
References
Ref 521412	ClinicalTrials.gov (NCT00000654) The Tolerance of HIV-Infected Patients With Herpes Group Virus Infections to Oral Doses of FIAU. U.S. National Institutes of Health.
Ref 534117	Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3592-7.

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