Drug Information

Drug General Information
Drug ID
D01NHJ
Former ID
DIB010875
Drug Name
AUY922
Synonyms
HSP90 inhibitors
Drug Type
Small molecular drug
Indication Myeloma [ICD9: 203; ICD10:C90] Phase 2 [524290]
Company
Novartis Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C26H31N3O5
Canonical SMILES
CCNC(=O)C1=C(C(=C2C=C(C(=CC2=O)O)C(C)C)ON1)C3=CC=C(C=C3<br />)CN4CCOCC4
InChI
1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,28,30H,4,9-12,15H2,1-3H3,(H,27,32)/b25-20-
InChIKey
SWDZPNJZKUGIIH-QQTULTPQSA-N
PubChem Compound ID
10096043
PubChem Substance ID
15083415, 39155921, 46484819, 49689000, 76608378, 99436965, 103556527, 124756976, 125163781, 126581936, 126738735, 131480668, 135727472, 136367275, 136367858, 136920354, 137245317, 138971951, 140671853, 143499493, 144116295, 152105921, 152237713, 152258028, 152258131, 152344085, 160646970, 162011585, 162037415, 162202735, 163642590, 164044840, 164193951, 174530564, 177748703, 185975634, 188899501, 198974570, 223401065, 223448353, 223680473, 228770821, 249814513, 251963184, 251971001, 252160237, 252215929
Target and Pathway
Target(s) Heat shock protein HSP90 Target Info Inhibitor [532267]
References
Ref 524290ClinicalTrials.gov (NCT01854034) Phase 2 Study of AUY922 in NSCLC Patients With Exon 20 Insertion Mutations in EGFR. U.S. National Institutes of Health.
Ref 532267The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth. Mol Cancer Ther. 2013 Jun;12(6):890-900.

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