Drug Information

Drug General Information
Drug ID
D0G5PF
Former ID
DNCL003108
Drug Name
AFQ056
Synonyms
Mavoglurant
Drug Type
Small molecular drug
Indication Fragile X syndrome [ICD9: 332, 759.83; ICD10:F02.3, G20, Q99.2] Phase 2/3 [523621], [542576]
Company
Novartis
Structure
Download
2D MOL

3D MOL
Formula
C19H23NO3
InChI
InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)8-11-19(22)10-4-7-17-16(19)9-12-20(17)18(21)23-2/h3,5-6,13,16-17,22H,4,7,9-10,12H2,1-2H3/t16-,17-,19-/m1/s1
InChIKey
ZFPZEYHRWGMJCV-ZHALLVOQSA-N
PubChem Compound ID
9926832
PubChem Substance ID
15189549, 24203078, 80377956, 99431574, 138546101, 163642446, 186528500, 194186363, 194940981, 198936767, 223365921, 223933254, 227245120, 247392681, 251879267, 252215755
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator [532401]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 523621ClinicalTrials.gov (NCT01433354) Long-term, Safety and Tolerability Study of AFQ056 in Adolescent Patients With Fragile X Syndrome (Open-label). U.S. National Institutes of Health.
Ref 542576(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7586).
Ref 532401Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects. Drug Metab Dispos. 2013 Sep;41(9):1626-41.

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