Drug Information

Drug General Information
Drug ID
D0L5UO
Former ID
DCL000102
Drug Name
Darapladib
Synonyms
SB 480848; Darapladib (USAN)
Drug Type
Small molecular drug
Indication Arteriosclerosis [ICD9: 440; ICD10:I70] Discontinued in Phase 3 [541801], [547463]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C36H38F4N4O2S
InChI
InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3
InChIKey
WDPFJWLDPVQCAJ-UHFFFAOYSA-N
CAS Number
CAS 356057-34-6
PubChem Compound ID
9939609
PubChem Substance ID
14912817, 17397748, 24212669, 51238364, 57373852, 103163821, 104017492, 123055336, 131311864, 134338793, 135195691, 137124696, 140342334, 144115884, 162201858, 163620709, 163686026, 170502612, 175426322, 178103307, 179150370, 185974990, 188932643, 190861993, 198984335, 223385373, 223704897, 228826696, 242060329, 243523950, 249737039, 251971364, 252155042, 252215249, 252451735, 252810760
Target and Pathway
Target(s) Phospholipase A2 Target Info Modulator [552985]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorption
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Glycerophospholipid biosynthesis
References
Ref 541801(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6696).
Ref 547463Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016591)
Ref 552985Darapladib, a reversible lipoprotein-associated phospholipase A2 inhibitor, for the oral treatment of atherosclerosis and coronary artery disease. IDrugs. 2009 Oct;12(10):648-55.

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