Drug General Information
Drug ID
D0NN8N
Former ID
DNCL001691
Drug Name
TNX-102
Synonyms
Cyclobenzaprine very low dose
Drug Type
Small molecular drug
Indication Fibromyalgia [ICD9: 729.1; ICD10:M79.7] Phase 3 [547624]
Company
TONIX Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C20H22ClN
Canonical SMILES
CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31.Cl
InChI
1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H
InChIKey
VXEAYBOGHINOKW-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Antagonist [551739]
5-hydroxytryptamine 2A receptor Target Info Antagonist [551739]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, Other
References
Ref 547624Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017946)
Ref 551739Clinical pipeline report, company report or official report of Tonix Pharmaceuticals.

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