Drug Information

Drug General Information
Drug ID
D09UAI
Former ID
DND000054
Drug Name
TB-402
Synonyms
Anti-FVIII MAb 2E9; MAb-LE2E9; TGX-LE2E9
Drug Type
Antibody
Indication Atrial fibrillation [ICD9: 272, 427.31; ICD10:E78, I48] Phase 2 [522492]
Company
ThromboGenics
Target and Pathway
Target(s) Coagulation Factor VIIIa Target Info [543658]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
PathWhiz Pathway Coagulation
Reactome Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Complement and Coagulation Cascades
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 522492ClinicalTrials.gov (NCT00793234) Single Intravenous Administration of TB-402 for the Prophylaxis of Venous Thromboembolic Events (VTE) After Total Knee Replacement Surgery. U.S. National Institutes of Health.
Ref 543658(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2607).

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