Drug General Information
Drug ID
D00BWF
Former ID
DNCL001689
Drug Name
AGN-XX/YY
Synonyms
Rezatomidine
Drug Type
Small molecular drug
Indication Diabetic nephropathy; Fibromyalgia [ICD9: 250.4, 729.1; ICD10:E11.21, M79.7] Phase 2 [549889]
Company
ACADIA Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C13H16N2S
Canonical SMILES
CC1=C(C(=CC=C1)C(C)C2=CNC(=S)N2)C
InChI
1S/C13H16N2S/c1-8-5-4-6-11(9(8)2)10(3)12-7-14-13(16)15-12/h4-7,10H,1-3H3,(H2,14,15,16)/t10-/m0/s1
InChIKey
WQXVKEDUCPMRRI-JTQLQIEISA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Agonist [550943]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 549889Clinical pipeline report, company report or official report of ACADIA Pharmaceuticals.
Ref 550943Patent WO2008058220 A2.

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