Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0C8KF
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| Former ID |
DCL000215
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| Drug Name |
Resiquimod
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| Synonyms |
Resiquimod [INN]; R 848; S 28463; R-848; S-28463; VML-600; 1-(4-Amino-2-ethoxymethyl-imidazo[4,5-c]quinolin-1-yl)-2-methyl-propan-2-ol; 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 4-amino-2-(ethoxymethyl)-a,a-dimethyl-1h-imidazo[4,5-c]quinoline-1-ethanol; 4-amino-2-ethoxymethyl-alpha,alpha-dimethyl-1H-imidazo(4,5-c)quinoline-1-ethanol
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| Drug Type |
Small molecular drug
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| Company |
3M Pharma.
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| Structure |
|
Download2D MOL |
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| Formula |
C17H22N4O2
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| InChI |
InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
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| InChIKey |
BXNMTOQRYBFHNZ-UHFFFAOYSA-N
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| CAS Number |
CAS 144875-48-9
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3721870, 10253655, 12014952, 14850224, 17425420, 46234815, 50987434, 53787617, 53787700, 56310917, 56314233, 57348724, 99030027, 103137407, 103137408, 103481674, 104098572, 113442759, 117524042, 125823193, 127582362, 134338879, 135115623, 137001879, 141757820, 160828723, 162023641, 162023642, 162023652, 163093686, 163390245, 163820535, 163842421, 172093316, 178101746, 179149939, 180674503, 185979111, 198951685, 204427635, 210274952, 210280590, 223383296, 223503036, 223592720, 223704642, 223775289, 226420675, 242068671, 249841086
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| ChEBI ID |
ChEBI:36706
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| Target and Pathway | |||||
| Target(s) | Toll-like receptor 7 | Target Info | Modulator | ||
| Toll-like receptor 8 | Target Info | Modulator | |||
| Reactome | Trafficking and processing of endosomal TLR | ||||
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | |||||
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | |||||
| MyD88 dependent cascade initiated on endosomeR-HSA-1679131:Trafficking and processing of endosomal TLR | |||||
| MyD88 dependent cascade initiated on endosome | |||||
| WikiPathways | Toll-like receptor signaling pathway | ||||
| Toll-Like Receptors Cascades | |||||
| MyD88 dependent cascade initiated on endosome | |||||
| Trafficking and processing of endosomal TLR | |||||
| Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway | |||||
| Regulation of toll-like receptor signaling pathway | |||||
| References | |||||
| Ref 468141 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5051). | ||||
| Ref 546884 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010858) | ||||
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