Drug Information

Drug General Information
Drug ID
D0K8IX
Former ID
DNC001431
Drug Name
Thiazolidinedione
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Approved [526111]
Structure
Download
2D MOL

3D MOL
Formula
C3H3NO2S
Canonical SMILES
C1C(=O)NC(=O)S1
InChI
1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
InChIKey
ZOBPZXTWZATXDG-UHFFFAOYSA-N
CAS Number
CAS 2295-31-0
PubChem Compound ID
5437
PubChem Substance ID
72705, 609107, 3136030, 5646729, 8153347, 10514447, 14747535, 24863353, 29224487, 36658754, 37339821, 37454049, 50052212, 53790560, 56311219, 56394927, 57322779, 57802988, 72264596, 78732118, 81041520, 87577683, 87917067, 92720016, 93373964, 96107609, 103289393, 104309239, 104668315, 117671506, 117687045, 118053742, 124526817, 125345461, 126576294, 126603281, 126620337, 126658467, 126668350, 126734391, 127114530, 127304974, 127304975, 127304976, 127304977, 127304978, 127304979, 127304980, 127304981, 127304982
ChEBI ID
ChEBI:50992
Target and Pathway
Target(s) Peroxisome proliferator activated receptor gamma Target Info Agonist [535579]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma protein
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear Receptors
References
Ref 526111Thiazolidinediones: a comparative review of approved uses. Diabetes Technol Ther. 2000 Autumn;2(3):429-40.
Ref 535579Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov;8(11):1281-7. Epub 2002 Oct 15.

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