Drug General Information
Drug ID
D03ONZ
Former ID
DIB008942
Drug Name
MCS-18
Synonyms
Helleborus purpurascens-derived anti-inflammatory analgesic (injection, autoimmune disease), DoNatur
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 2 [529495]
Company
DoNatur GmbH
Structure
Download
2D MOL
Canonical SMILES
c12c3oc4c(C1)oc1c(=O)c5c(c(=O)c6c(o5)c(=O)c(c(o6)c3=O)o<br />2)oc1c4=O
Target and Pathway
Target(s) Toll-like receptor 2 Target Info Modulator [529495]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Herpes simplex infection
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signaling
Reactome Beta defensins
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
WikiPathways Toll-like receptor signaling pathway
IL1 and megakaryotyces in obesity
Human Complement System
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
Defensins
Regulation of toll-like receptor signaling pathway
References
Ref 529495The novel arthritis-drug substance MCS-18 attenuates the antibody production in vivo. Acta Microbiol Immunol Hung. 2008 Mar;55(1):15-31.
Ref 529495The novel arthritis-drug substance MCS-18 attenuates the antibody production in vivo. Acta Microbiol Immunol Hung. 2008 Mar;55(1):15-31.

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