Drug General Information
Drug ID
D03QIE
Former ID
DCL000723
Drug Name
Bicifadine
Drug Type
Small molecular drug
Indication Chronic low back pain; Neuropathic pain [ICD9: 338, 356.0, 356.8, 724.2, 724.5,780; ICD10:G64, G90.0, M54, M54.5, R52, G89] Phase 3 [536374]
Therapeutic Class
Analgesics
Company
Dov Pharmaceutical
Structure
Download
2D MOL

3D MOL

Formula
C12H15N
Canonical SMILES
CC1=CC=C(C=C1)C23CC2CNC3
InChI
1S/C12H15N/c1-9-2-4-10(5-3-9)12-6-11(12)7-13-8-12/h2-5,11,13H,6-8H2,1H3
InChIKey
OFYVIGTWSQPCLF-UHFFFAOYSA-N
CAS Number
CAS 71195-57-8
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
L01XX22
SuperDrug CAS ID
cas=005300038
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Modulator
Sodium-dependent serotonin transporter Target Info Modulator
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
SIDS Susceptibility Pathways
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 536374Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.

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