Drug General Information
Drug ID	D0M6BA
Former ID	DNCL002406
Drug Name	AR-67
Drug Type	Small molecular drug
Indication	Glioblastoma multiforme; Myelodysplastic syndrome [ICD9: 191, 238.7; ICD10:C71, D46]		Phase 2	[523046]
Company	Arno Therapeutics
Structure		Download 2D MOL 3D MOL
Formula	C26H30N2O5Si
PubChem Compound ID	6712744
Target and Pathway
Target(s)	Toposisomerase-1	Target Info	Inhibitor	[532769]
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	DNA replication
Pathway Interaction Database	Caspase Cascade in Apoptosis
WikiPathways	Integrated Pancreatic Cancer Pathway
References
Ref 523046	ClinicalTrials.gov (NCT01124539) Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma. U.S. National Institutes of Health.
Ref 532769	Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans. Cancer Chemother Pharmacol. 2014 Jul;74(1):45-54.

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