Drug Information

Drug General Information
Drug ID
D0Z5HR
Former ID
DIB009120
Drug Name
VX-661
Synonyms
CFTR correctors (cystic fibrosis), Vertex; Cystic fibrosis transmembrane regulator corrector (cystic fibrosis), Vertex
Drug Type
Small molecular drug
Indication Cystic fibrosis [ICD9: 277; ICD10:E84] Phase 2 [525275]
Company
Vertex Pharmaceuticals Inc
Structure
Download
2D MOL

3D MOL
Formula
C26H27F3N2O6
Canonical SMILES
CC(C)(CO)C1=CC2=CC(=C(C=C2N1CC(CO)O)F)NC(=O)C3(CC3)C4=C<br />C5=C(C=C4)OC(O5)(F)F
InChI
1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1
InChIKey
MJUVRTYWUMPBTR-MRXNPFEDSA-N
PubChem Compound ID
46199646
PubChem Substance ID
96053596, 120466965, 138151262, 138798168, 140416866, 163620885, 163686208, 163770942, 164178299, 165245604, 170502668, 184823505, 189254077, 224274711, 226660026, 235375449, 248389873, 249734895, 251910604, 252155499, 252160789, 252163519, 252228808, 252319752, 252553650, 252811067
Target and Pathway
Target(s) cystic fibrosis transmembrane conductance regulator Target Info Regulator [532904]
KEGG Pathway ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Reactome ABC-family proteins mediated transport
WikiPathways ABC-family proteins mediated transport
References
Ref 525275ClinicalTrials.gov (NCT02508207) A Phase 2 Study to Evaluate Effects of VX-661/Ivacaftor on Lung and Extrapulmonary Systems in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation.
Ref 532904CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39(7):500-11.

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