Drug Information

Drug General Information
Drug ID
D08SHE
Former ID
DNCL003104
Drug Name
SEP-228432
Indication Depressive disorders; Neuropathic pain [ICD9: 296, 710.0, 356.0, 356.8; ICD10:F30-F39, M32, G64, G90.0] Phase 1 [523795]
Company
Sunovion Pharmaceuticals
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [548778]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 523795ClinicalTrials.gov (NCT01531972) A Phase 1, Open-Label, Single-photon Emission Computed Tomography (SPECT) Study to Evaluate Serotonin and Dopamine Transporter Occupancy After Multiple Dose Administration of SEP-228432 to Achieve Steady State in Healthy Subjects. U.S. National Institutes of Health.
Ref 548778Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028715)

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