| Drug General Information |
| Drug ID |
D08JXW
|
| Former ID |
DIB008023
|
| Drug Name |
INS-117548
|
| Synonyms |
ROCKI/ROCKII inhibitor (ophthalmic solution, ocular hypertension/glaucoma), Wisconsin Alumni Research Foundation (WARF)/Inspire
|
| Indication |
Glaucoma [ICD9: 365; ICD10:H40-H42]
|
Phase 1 |
[1]
|
|---|
| Company |
University of Wisconsin-Madison
|
| Structure |
|
Download
2D MOL
3D MOL
|
| Canonical SMILES |
[nH]1ncc2cc(ccc12)NC1CN(CCC1)Cc1ccc(cc1)SC
|
| Target and Pathway |
| Target(s) |
Rho associated protein kinase 2 |
Target Info |
Modulator |
[2]
|
|---|
| Rho-associated protein kinase 1 |
Target Info |
Modulator |
[2]
|
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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Sphingolipid signaling pathway
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Vascular smooth muscle contraction
|
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Wnt signaling pathway
|
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Axon guidance
|
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Focal adhesion
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Platelet activation
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Leukocyte transendothelial migration
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Regulation of actin cytoskeleton
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Oxytocin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
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Pathways in cancer
|
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Proteoglycans in cancerhsa04022:cGMP-PKG signaling pathway
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TGF-beta signaling pathway
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Proteoglycans in cancer
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MicroRNAs in cancer
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PANTHER Pathway
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Cytoskeletal regulation by Rho GTPaseP00016:Cytoskeletal regulation by Rho GTPase
|
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Inflammation mediated by chemokine and cytokine signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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RhoA signaling pathway
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Plasma membrane estrogen receptor signaling
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Osteopontin-mediated events
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PLK1 signaling events
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PAR4-mediated thrombin signaling events
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PAR1-mediated thrombin signaling events
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Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
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Noncanonical Wnt signaling pathway
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EPHB forward signaling
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Thromboxane A2 receptor signaling
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amb2 Integrin signaling
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Integrins in angiogenesis
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EPHA forward signaling
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
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N-cadherin signaling events
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Reactome
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EPHB-mediated forward signaling
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EPHA-mediated growth cone collapse
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G alpha (12/13) signalling events
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Sema4D induced cell migration and growth-cone collapse
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VEGFA-VEGFR2 Pathway
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RHO GTPases Activate ROCKsR-HSA-111465:Apoptotic cleavage of cellular proteins
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RHO GTPases Activate ROCKs
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WikiPathways
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G13 Signaling Pathway
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Regulation of Actin Cytoskeleton
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Focal Adhesion
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JAK/STAT
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Spinal Cord Injury
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Pathogenic Escherichia coli infection
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Leptin signaling pathway
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Semaphorin interactions
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Integrin-mediated Cell Adhesion
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GPCR downstream signaling
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MicroRNAs in cardiomyocyte hypertrophy
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Androgen receptor signaling pathwayWP524:G13 Signaling Pathway
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EGF/EGFR Signaling Pathway
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TGF beta Signaling Pathway
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AGE/RAGE pathway
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Regulation of Microtubule Cytoskeleton
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Apoptotic execution phase
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Androgen receptor signaling pathway
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| References |
| REF 1 | ClinicalTrials.gov (NCT00767793) A Placebo-Controlled Study of INS117548 Ophthalmic Solution in Subjects With Glaucoma (P08650). U.S. National Institutes of Health. |
|---|
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. |
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