Drug General Information |
Drug ID |
D08JXW
|
Former ID |
DIB008023
|
Drug Name |
INS-117548
|
Synonyms |
ROCKI/ROCKII inhibitor (ophthalmic solution, ocular hypertension/glaucoma), Wisconsin Alumni Research Foundation (WARF)/Inspire
|
Indication |
Glaucoma [ICD9: 365; ICD10:H40-H42]
|
Phase 1 |
[1]
|
Company |
University of Wisconsin-Madison
|
Structure |
|
Download
2D MOL
3D MOL
|
Canonical SMILES |
[nH]1ncc2cc(ccc12)NC1CN(CCC1)Cc1ccc(cc1)SC
|
Target and Pathway |
Target(s) |
Rho associated protein kinase 2 |
Target Info |
Modulator |
[2]
|
Rho-associated protein kinase 1 |
Target Info |
Modulator |
[2]
|
KEGG Pathway
|
cGMP-PKG signaling pathway
|
cAMP signaling pathway
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Chemokine signaling pathway
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Sphingolipid signaling pathway
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Vascular smooth muscle contraction
|
Wnt signaling pathway
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Axon guidance
|
Focal adhesion
|
Platelet activation
|
Leukocyte transendothelial migration
|
Regulation of actin cytoskeleton
|
Oxytocin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
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Pathways in cancer
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Proteoglycans in cancerhsa04022:cGMP-PKG signaling pathway
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TGF-beta signaling pathway
|
Proteoglycans in cancer
|
MicroRNAs in cancer
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PANTHER Pathway
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Cytoskeletal regulation by Rho GTPaseP00016:Cytoskeletal regulation by Rho GTPase
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Inflammation mediated by chemokine and cytokine signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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RhoA signaling pathway
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Plasma membrane estrogen receptor signaling
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Osteopontin-mediated events
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PLK1 signaling events
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PAR4-mediated thrombin signaling events
|
PAR1-mediated thrombin signaling events
|
Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
|
Noncanonical Wnt signaling pathway
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EPHB forward signaling
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Thromboxane A2 receptor signaling
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amb2 Integrin signaling
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Integrins in angiogenesis
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EPHA forward signaling
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
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N-cadherin signaling events
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Reactome
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EPHB-mediated forward signaling
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EPHA-mediated growth cone collapse
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G alpha (12/13) signalling events
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Sema4D induced cell migration and growth-cone collapse
|
VEGFA-VEGFR2 Pathway
|
RHO GTPases Activate ROCKsR-HSA-111465:Apoptotic cleavage of cellular proteins
|
RHO GTPases Activate ROCKs
|
WikiPathways
|
G13 Signaling Pathway
|
Regulation of Actin Cytoskeleton
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Focal Adhesion
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JAK/STAT
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Spinal Cord Injury
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Pathogenic Escherichia coli infection
|
Leptin signaling pathway
|
Semaphorin interactions
|
Integrin-mediated Cell Adhesion
|
GPCR downstream signaling
|
MicroRNAs in cardiomyocyte hypertrophy
|
Androgen receptor signaling pathwayWP524:G13 Signaling Pathway
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EGF/EGFR Signaling Pathway
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TGF beta Signaling Pathway
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AGE/RAGE pathway
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Regulation of Microtubule Cytoskeleton
|
Apoptotic execution phase
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Androgen receptor signaling pathway
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References |
REF 1 | ClinicalTrials.gov (NCT00767793) A Placebo-Controlled Study of INS117548 Ophthalmic Solution in Subjects With Glaucoma (P08650). U.S. National Institutes of Health. |
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REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. |