Drug Information

Drug General Information
Drug ID
D06AXY
Former ID
DCL000779
Drug Name
DOV 21947
Drug Type
Small molecular drug
Indication Severe mood disorders [ICD9: 296; ICD10:F30-F39] Phase 2 [536580]
Company
DOV; Merck
Structure
Download
2D MOL

3D MOL
Formula
C11H12Cl3N
Canonical SMILES
C1C2C1(CNC2)C3=CC(=C(C=C3)Cl)Cl.Cl
InChI
1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H/t8-,11+;/m1./s1
InChIKey
KAGBHVBIOJBGBD-NINOIYOQSA-N
PubChem Compound ID
11680542
PubChem Substance ID
16784623, 23777082, 42847472, 79014991, 134455263, 135268705, 135626808, 163640960, 172912823, 198961264, 198979638, 230139451
Target and Pathway
Target(s) Dopamine reuptake Target Info Inhibitor [536580]
Sodium-dependent serotonin transporter Target Info Inhibitor [536580]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [536580]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.
Ref 536580Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. Epub 2008 Jan 2.

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