Drug Information

Drug General Information
Drug ID
D00GHZ
Former ID
DIB010384
Drug Name
Antiandrogens
Synonyms
Antiandrogens (prostate cancer); EM-4350; EM-5854; EM-6537; Antiandrogens (prostate cancer), Endoceutics; Androgen receptor antagonists (endocrine-related disorders), Endoceutics
Indication Endocrine disease [ICD10:E00-E35] Phase 2 [529385]
Company
Endorecherche Inc
Structure
Download
2D MOL

3D MOL
Canonical SMILES
[C@@]1(Cc2cc[n+](cc2)[O-])([C@]2(CC[C@@H]3c4ccc(c(c4CC[<br />C@H]3[C@@H]2CC1)F)C#N)C)O
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Androgen receptor Target Info Antagonist [531856]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 529385Phase II study of the pure non-steroidal antiandrogen nilutamide in prostatic cancer. Italian Prostatic Cancer Project (PONCAP). Eur J Cancer. 1991;27(9):1100-4.
Ref 531856Steroid derivatives as pure antagonists of the androgen receptor. J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):93-104.

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