Drug General Information
Drug ID	D01ZNH
Former ID	DIB006495
Drug Name	IDAZOXAN HYDROCHLORIDE
Drug Type	Small molecular drug
Indication	Neurological disease [ICD9: 338, 338.2, 410, 782.3,780; ICD10:I21, I22, R52, R52.1-R52.2, R60.9, G89]		Phase 3	[521807]
Structure		Download 2D MOL 3D MOL
Formula	C11H13ClN2O2
Canonical SMILES	C1CN=C(N1)C2COC3=CC=CC=C3O2.Cl
InChI	1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChIKey	MYUBYOVCLMEAOH-UHFFFAOYSA-N
CAS Number	CAS 79944-56-2
PubChem Compound ID	154494
PubChem Substance ID	855744, 10252163, 12013061, 15196433, 17405213, 24278493, 46230606, 49979459, 50106461, 50106462, 53777758, 56422421, 57348005, 80422800, 91704604, 92125798, 92304251, 103674322, 103913614, 104438906, 135108885, 135113275, 135697892, 144076197, 162226966, 163135164, 163564606, 164814671, 170485588, 175611453, 179148916, 223961152, 226998321, 241139428, 241181899, 241377485, 252350840
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Modulator	[526773]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 521807	ClinicalTrials.gov (NCT00294944) The Effectiveness of Idazoxan in Treating TRD. U.S. National Institutes of Health.
Ref 526773	Different sites of action for alpha 2-adrenoceptor antagonists in the modulation of noradrenaline release and contraction response in the vas deferens of the rat. J Pharm Pharmacol. 1992 Mar;44(3):231-4.

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