Drug Information

Drug General Information
Drug ID
D0R9ON
Former ID
DNC000960
Drug Name
MR-889
Drug Type
Small molecular drug
Indication Mucolytic [ICD10:J00-J99] Discontinued in Phase 3 [545562]
Structure
Download
2D MOL

3D MOL
Formula
C12H13NO3S3
Canonical SMILES
CC(C(=O)NC1CCSC1=O)SC(=O)C2=CC=CS2
InChI
1S/C12H13NO3S3/c1-7(19-12(16)9-3-2-5-17-9)10(14)13-8-4-6-18-11(8)15/h2-3,5,7-8H,4,6H2,1H3,(H,13,14)
InChIKey
MKTVMEMIKNBVHI-UHFFFAOYSA-N
CAS Number
CAS 94149-41-4
PubChem Compound ID
65837
PubChem Substance ID
8189972, 12014457, 14801193, 43122579, 50053844, 52511442, 57315768, 104334790, 128610040, 134339895, 134340240, 134436933, 135025536, 136356121, 137267712, 137393661, 141423607, 162755868, 179151454, 184547765, 227013172
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [535494]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 545562Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003709)
Ref 535494Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

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