Drug Information
Drug General Information | |||||
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Drug ID |
D01TBN
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Former ID |
DCL000800
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Drug Name |
Ezlopitant
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Synonyms |
Ezlopitant (USAN/INN); (2S,3S)-2-benzhydryl-N-[(2-methoxy-5-propan-2-ylphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine; (2s,3s)-2-(diphenylmethyl)-n-(5-isopropyl-2-methoxybenzyl)quinuclidin-3-amine; 2-benzhydryl-N-[(2-methoxy-5-propan-2-ylphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
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Drug Type |
Small molecular drug
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Company |
Pfizer
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Structure |
Download2D MOL |
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Formula |
C31H38N2O
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InChI |
InChI=1S/C31H38N2O/c1-22(2)26-14-15-28(34-3)27(20-26)21-32-30-25-16-18-33(19-17-25)31(30)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-15,20,22,25,29-32H,16-19,21H2,1-3H3/t30-,31-/m0/s1
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InChIKey |
XPNMCDYOYIKVGB-CONSDPRKSA-N
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CAS Number |
CAS 147116-64-1
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Substance-P receptor | Target Info | Antagonist | [536188] | |
PANTHER Pathway | CCKR signaling map ST | ||||
Reactome | G alpha (q) signalling events | ||||
References | |||||
Ref 536188 | Emerging drugs for chemotherapy-induced emesis. Expert Opin Emerg Drugs. 2006 Mar;11(1):137-51. | ||||
Ref 541086 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5751). |
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