Drug Information

Drug General Information
Drug ID
D09JXL
Former ID
DIB004472
Drug Name
SEGLITIDE
Synonyms
L-363586; MK-678; Seglitide < Rec INN >; Cyclic (N-Me-Ala-Tyr-D-Trp-Lys-Val-Phe)
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [539307], [544698]
Structure
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2D MOL

3D MOL
Formula
C44H56N8O7
InChI
InChI=1S/C44H56N8O7/c1-26(2)38-43(58)50-37(23-28-12-6-5-7-13-28)44(59)52(4)27(3)39(54)48-35(22-29-17-19-31(53)20-18-29)41(56)49-36(24-30-25-46-33-15-9-8-14-32(30)33)42(57)47-34(40(55)51-38)16-10-11-21-45/h5-9,12-15,17-20,25-27,34-38,46,53H,10-11,16,21-24,45H2,1-4H3,(H,47,57)(H,48,54)(H,49,56)(H,50,58)(H,51,55)/t27-,34-,35-,36+,37-,38-/m0/s1
InChIKey
NPJIOCBFOAHEDO-AVWFULIKSA-N
CAS Number
CAS 81377-02-8
PubChem Compound ID
5311430
PubChem Substance ID
7980586, 11056501, 12013791, 14767053, 17405661, 24278692, 48095633, 50953562, 53778211, 57359479, 92303183, 103284096, 103948563, 114156076, 124750239, 135652292, 162247263, 164814684, 179151224, 198979102, 226516290, 241375638, 249617401, 252156128, 252356607
Target and Pathway
Target(s) Somatostatin receptor Target Info Modulator [544040]
References
Ref 539307(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2051).
Ref 544698Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000642)
Ref 544040Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria.. Br J Pharmacol. 1993 August; 109(4): 898-899.

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