Drug Information

Drug General Information
Drug ID
D0H8WZ
Former ID
DIB004173
Drug Name
SR-43845
Synonyms
N-[3-(3-Pyridyl)propionyl]-L-phenylalanyl-L-histidyl-cyclostatinyl-L-isoleucyl-1,1-di(hydroxymethyl)ethylamide; N-[3-(3-Pyridyl)propionyl]-L-phenylalanyl-L-histidyl-(3S,4S)-4-amino-3-hydroxy-5-cyclohexylpentanoyl-L-isoleucyl-1,1-di(hydroxymethyl)ethylamide; [S-(R*,R*)]-5-Cyclohexyl-2,4,5-trideoxy-N-[1-[[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]carbonyl]-2-methylbutyl]-4-[[N-[N-[1-oxo-3-(3-pyridinyl)propyl]-L-phenylalanyl]-L-histidyl]amino-L-threo
Drug Type
Small molecular drug
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 2 [544840]
Structure
Download
2D MOL

3D MOL
Formula
C44H64N8O8
Canonical SMILES
CCC(C)C(C(=O)NC(C)(CO)CO)NC(=O)CC(C(CC1CCCCC1)NC(=O)C(C<br />C2=CN=CN2)NC(=O)C(CC3=CC=CC=C3)NC(=O)CCC4=CN=CC=C4)O
InChI
1S/C44H64N8O8/c1-4-29(2)40(43(60)52-44(3,26-53)27-54)51-39(57)23-37(55)34(20-30-12-7-5-8-13-30)49-42(59)36(22-33-25-46-28-47-33)50-41(58)35(21-31-14-9-6-10-15-31)48-38(56)18-17-32-16-11-19-45-24-32/h6,9-11,14-16,19,24-25,28-30,34-37,40,53-55H,4-5,7-8,12-13,17-18,20-23,26-27H2,1-3H3,(H,46,47)(H,48,56)(H,49,59)(H,50,58)(H,51,57)(H,52,60)
InChIKey
NZGWKVVFXREROW-UHFFFAOYSA-N
CAS Number
CAS 114037-60-4
PubChem Compound ID
163918
PubChem Substance ID
46238235, 78464413, 103097603, 113452788, 117571962, 135118939
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [533331], [551871]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 544840Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001290)
Ref 533331Effects of a renin inhibitor, SR 43845, and of captopril on blood pressure and plasma active renin in conscious sodium-replete macaca. J Hypertens Suppl. 1989 Apr;7(2):S33-5.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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