Drug Information

Drug General Information
Drug ID
D0VO6J
Former ID
DIB006593
Drug Name
FAD-104
Synonyms
ME-2303; (8S,10S)-8-(6-Carboxyhexanoyloxyacetyl)-10-[(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; 7-O-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyl)adriamycinone-14-O-hemipimelate; 7-O-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyl)pimelyladryamycinone
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 2 [544758]
Structure
Download
2D MOL

3D MOL
Formula
C34H37FO15
Canonical SMILES
CC1C(C(C(C(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)<br />C=CC=C5OC)O)(C(=O)COC(=O)CCCCCC(=O)O)O)F)O)O
InChI
1S/C34H37FO15/c1-14-27(40)32(45)26(35)33(49-14)50-18-12-34(46,19(36)13-48-21(39)10-5-3-4-9-20(37)38)11-16-23(18)31(44)25-24(29(16)42)28(41)15-7-6-8-17(47-2)22(15)30(25)43/h6-8,14,18,26-27,32-33,40,42,44-46H,3-5,9-13H2,1-2H3,(H,37,38)/t14-,18-,26+,27+,32-,33-,34-/m0/s1
InChIKey
PQMIPLRIRFVQJZ-QBYYVRQOSA-N
CAS Number
CAS 116521-53-0
PubChem Compound ID
115362
PubChem Substance ID
10236753, 15088662, 29296852, 49975363, 57339136, 78805194, 104398201, 135072801, 136067894
Target and Pathway
Target(s) Human DNA Target Info Binder [528401]
References
Ref 544758Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000888)
Ref 528401Biological activities of new anthracyclines containing fluorine, FAD104 and its metabolites. J Antibiot (Tokyo). 1990 May;43(5):556-65.

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