Drug Information

Drug General Information
Drug ID
D07UOS
Former ID
DIB000414
Drug Name
MK-434
Synonyms
17beta-Benzoyl-4-aza-5alpha-androst-1-en-3-one
Drug Type
Small molecular drug
Indication Prostate disease [ICD10:N42.9] Discontinued in Phase 1 [545935]
Structure
Download
2D MOL

3D MOL
Formula
C25H31NO2
Canonical SMILES
CC12CCC3C(C1CCC2C(=O)C4=CC=CC=C4)CCC5C3(C=CC(=O)N5)C
InChI
1S/C25H31NO2/c1-24-14-12-19-17(8-11-21-25(19,2)15-13-22(27)26-21)18(24)9-10-20(24)23(28)16-6-4-3-5-7-16/h3-7,13,15,17-21H,8-12,14H2,1-2H3,(H,26,27)/t17-,18-,19-,20+,21+,24-,25+/m0/s1
InChIKey
ZYTQEOWFSVTRLX-QKONGSNMSA-N
CAS Number
CAS 134067-56-4
PubChem Compound ID
131705
PubChem Substance ID
10242936, 14804440, 29310005, 57343878, 80742699, 104375710, 135085992, 233696137
Target and Pathway
Target(s) 5-alpha reductase Target Info Inhibitor [534422], [551871]
References
Ref 545935Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005411)
Ref 534422The effects of progesterone, 4,16-androstadien-3-one and MK-434 on the kinetics of pig testis microsomal testosterone-4-ene-5alpha-reductase activity. J Steroid Biochem Mol Biol. 1997 Mar;60(5-6):353-9.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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