Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D09FZI
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| Former ID |
DIB013143
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| Drug Name |
TALTOBULIN
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| Synonyms |
HTI-286; SPA-110 (trifluoroacetate salt); Taltobulin < Prop INN >; N,3,3-Trimethyl-L-phenylalanyl-N1-[3-carboxy-1(S)-isopropyl-2(E)-butenyl]-N1,3-dimethyl-L-valinamide
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| Drug Type |
Small molecular drug
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| Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Discontinued in Phase 1 | [547769] | ||
| Structure |
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Download2D MOL |
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| Formula |
C27H43N3O4
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| Canonical SMILES |
CN[C@H](C(=O)N[C@H](C(=O)N(C)[C@H](\\C=C(/C)\\C(=O)O)C(<br />C)C)C(C)(C)C)C(C)(C)c1ccccc1
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| InChI |
1S/C27H43N3O4/c1-17(2)20(16-18(3)25(33)34)30(10)24(32)22(26(4,5)6)29-23(31)21(28-9)27(7,8)19-14-12-11-13-15-19/h11-17,20-22,28H,1-10H3,(H,29,31)(H,33,34)/b18-16+/t20-,21-,22-/m1/s1
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| InChIKey |
CNTMOLDWXSVYKD-PSRNMDMQSA-N
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| CAS Number |
CAS 228266-40-8
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Tubulin | Target Info | Inhibitor | [530691], [551871] | |
| References | |||||
| Ref 530691 | Absolute configurations of tubulin inhibitors taltobulin (HTI-286) and HTI-042 characterized by X-ray diffraction analysis and NMR studies. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1535-8. | ||||
| Ref 551871 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
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