Drug Information

Drug General Information
Drug ID
D0V4YO
Former ID
DIB015521
Drug Name
ROCICLOVIR
Synonyms
Hoe-602; Rociclovir < Rec INN >; 2-Amino-9-[1,3-bis(isopropoxy)-2-propyloxymethyl]purine; 6-Deoxy-9-(1-isopropoxymethyl-2-isopropoxyethoxymethyl)guanine
Drug Type
Small molecular drug
Indication Viral infections [ICD9: 054.0, 054.1, 054.2, 054.3, 075, 771.2, 052, 053; ICD10:B01, B02, A60, B00, B27, G05.1, P35.2] Phase 1 [544783]
Structure
Download
2D MOL

3D MOL
Formula
C15H25N5O3
Canonical SMILES
CC(C)OCC(COC(C)C)OCn1cnc2cnc(N)nc12
InChI
1S/C15H25N5O3/c1-10(2)21-6-12(7-22-11(3)4)23-9-20-8-18-13-5-17-15(16)19-14(13)20/h5,8,10-12H,6-7,9H2,1-4H3,(H2,16,17,19)
InChIKey
FBHWXSOQXQBXER-UHFFFAOYSA-N
CAS Number
CAS 108436-80-2
PubChem Compound ID
65905
Target and Pathway
Target(s) DNA polymerase Target Info Modulator [533031], [551871]
References
Ref 544783Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001059)
Ref 533031Herpes simplex virus type 1 DNA polymerase. Mechanism of inhibition by acyclovir triphosphate. J Biol Chem. 1989 May 5;264(13):7405-11.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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