Drug Information

Drug General Information
Drug ID
D0PM9P
Former ID
DIB001282
Drug Name
KB-5246
Synonyms
9,1-Epoxymethano-7-fluoro-8-(4-methyl-1-piperazinyl)-5-oxo-5H-thiazolo[3,2-a]quinoline-4-carboxylic acid hydrochloride
Drug Type
Small molecular drug
Indication Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Terminated [544660]
Structure
Download
2D MOL

3D MOL
Formula
C18H19ClFN3O4S
Canonical SMILES
CN1CCN(CC1)C2=C3C4C5C(=C2F)CC(=O)C(=C5SN=C4CO3)C(=O)O.C<br />l
InChI
1S/C18H18FN3O4S.ClH/c1-21-2-4-22(5-3-21)15-14(19)8-6-10(23)13(18(24)25)17-11(8)12-9(20-27-17)7-26-16(12)15;/h11-12H,2-7H2,1H3,(H,24,25);1H
InChIKey
URZNPRNEDQSWGC-UHFFFAOYSA-N
CAS Number
CAS 119474-55-4
PubChem Compound ID
197271
PubChem Substance ID
33517193, 50000632, 50500693, 113464868, 126453664, 135175357
Target and Pathway
Target(s) Bacterial DNA gyrase Target Info Modulator [544015]
References
Ref 544660Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000463)
Ref 544015Activity of KB-5246 against outer membrane mutants of Escherichia coli and Salmonella typhimurium.. Antimicrob Agents Chemother. 1990 July; 34(7): 1323-1325.

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