Drug Information

Drug General Information
Drug ID
D0JL2K
Former ID
DAP001005
Drug Name
Grepafloxacin
Synonyms
Raxar; Grepafloxacin [INN]; Grepafloxacin (unspecified); Raxar (TN); (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-5-methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Drug Type
Small molecular drug
Indication Chronic bronchitis [ICD10:J42] Approved [551871]
Bacterial infections [ICD9: 001-009, 010-018, 020-027, 030-041, 080-088, 090-099, 100-104; ICD10:A00-B99] Withdrawn from market [538554]
Therapeutic Class
Antibiotics
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C19H22FN3O3
Canonical SMILES
CC1CN(CCN1)C2=C(C(=C3C(=C2)N(C=C(C3=O)C(=O)O)C4CC4)C)F
InChI
1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey
AIJTTZAVMXIJGM-UHFFFAOYSA-N
CAS Number
CAS 119914-60-2
PubChem Compound ID
72474
PubChem Substance ID
13542, 603312, 6610845, 8195206, 14852426, 43128629, 46507253, 50042505, 50112780, 50471882, 53788063, 57318735, 103179577, 104011329, 104353024, 124766026, 125536480, 127411146, 134338274, 135029665, 137044453, 143019201, 160963712, 162793470, 163693542, 163852853, 179148061, 184545887, 184546334, 223439875, 224916848, 226420671, 241036011, 242059760
SuperDrug ATC ID
J01MA11
SuperDrug CAS ID
cas=119914602
Target and Pathway
Target(s) Bacterial DNA gyrase Target Info Modulator
References
Ref 538554FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020695.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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