Drug General Information
Drug ID
D0Z9GJ
Former ID
DNC001479
Drug Name
U 75302
Drug Type
Small molecular drug
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Terminated [540285], [544531]
Structure
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2D MOL

3D MOL

Formula
C22H35NO3
InChI
InChI=1S/C22H35NO3/c1-2-3-4-5-6-7-13-21(25)16-15-19-11-10-12-20(23-19)18-22(26)14-8-9-17-24/h6-7,10-12,15-16,21-22,24-26H,2-5,8-9,13-14,17-18H2,1H3/b7-6-,16-15+/t21-,22+/m1/s1
InChIKey
JNBOAUIJLDEICX-LJCAKPRGSA-N
CAS Number
CAS 119477-85-9
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Leukotriene B4 receptor 1 Target Info Antagonist [535025]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
GPCR ligand binding
GPCR downstream signaling
References
Ref 540285(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3325).
Ref 544531Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000072)
Ref 535025A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000 Aug 7;192(3):421-32.

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