Drug General Information
Drug ID	D0N3TO
Former ID	DIB002722
Drug Name	TRM-115
Synonyms	TRM-15
Drug Type	Small molecular drug
Indication	Gastric ulcer [ICD9: 531; ICD10:K25]		Discontinued in Phase 1	[545104]
Company	Terumo Corp
Structure		Download 2D MOL 3D MOL
Formula	C27H36N4O4S
Canonical SMILES	C(=S)(Nc1cc2c(OCO2)cc1)NCCCC(=O)NCCCOc1cc(CN2CCCCC2)ccc<br />1
CAS Number	CAS 147779-46-2
PubChem Compound ID	6918243
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Antagonist	[545105]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545104	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002138)
Ref 545105	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002138)

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