Drug General Information
Drug ID	D07RUV
Former ID	DIB000959
Drug Name	Terflavoxate
Synonyms	ND-907; Rec-15-2053
Drug Type	Small molecular drug
Indication	Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32]		Discontinued in Phase 2	[545426]
Company	Recordati SpA
Structure		Download 2D MOL 3D MOL
Formula	C26H29NO4
Canonical SMILES	c12oc(c(c(=O)c2cccc1C(=O)OC(CN1CCCCC1)(C)C)C)c1ccccc1.C<br />l
PubChem Compound ID	135750
Target and Pathway
Target(s)	Muscarinic receptor	Target Info	Modulator	[534003]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	PI3K-Akt signaling pathway
	Cholinergic synapse
	Regulation of actin cytoskeleton
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545426	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003221)
Ref 534003	Effects of terflavoxate on stimulated contractions of urinary bladder in vitro. Arzneimittelforschung. 1993 Feb;43(2):122-8.

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