Drug Information

Drug General Information
Drug ID
D03XDX
Former ID
DCL000244
Drug Name
Tarazepide
Synonyms
Tarazepide (INN)
Drug Type
Small molecular drug
Indication Gastrointestinal disease [ICD10:K00-K93] Discontinued in Phase 2 [525387]
Company
Solvay Pharma
Structure
Download
2D MOL

3D MOL
Formula
C28H24N4O2
Canonical SMILES
CN1C2=CC=CC=C2C(=NC(C1=O)NC(=O)C3=CC4=C5N3CCCC5=CC=C4)C<br />6=CC=CC=C6
InChI
1S/C28H24N4O2/c1-31-22-15-6-5-14-21(22)24(18-9-3-2-4-10-18)29-26(28(31)34)30-27(33)23-17-20-12-7-11-19-13-8-16-32(23)25(19)20/h2-7,9-12,14-15,17,26H,8,13,16H2,1H3,(H,30,33)/t26-/m1/s1
InChIKey
CZPILLBHPRAPCB-AREMUKBSSA-N
CAS Number
CAS 141374-81-4
PubChem Compound ID
10343641
PubChem Substance ID
15355111, 17396877, 22707749, 33976694, 52404212, 57410621, 134338904, 135727694, 137263964, 160666618, 198987706, 227532086, 241034831
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Antagonist [536339], [536595], [538151]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 525387Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. BMC Neurosci. 2012 Jun 8;13:63.
Ref 536339The ghrelin pentapeptide inhibits the secretion of pancreatic juice in rats. J Physiol Pharmacol. 2006 Dec;57(4):691-700.
Ref 536595Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol. 2007 Dec;58 Suppl 6:65-80.
Ref 538151Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves. Regul Pept. 1998 Nov 30;78(1-3):113-23.

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