Drug Information

Drug General Information
Drug ID
D09YUQ
Former ID
DIB011651
Drug Name
SR-11237
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Terminated [539850], [545989]
Company
Sanofi
Structure
Download
2D MOL

3D MOL
Formula
C24H28O4
InChI
InChI=1S/C24H28O4/c1-22(2)11-12-23(3,4)20-15-18(9-10-19(20)22)24(27-13-14-28-24)17-7-5-16(6-8-17)21(25)26/h5-10,15H,11-14H2,1-4H3,(H,25,26)
InChIKey
ZZUKALQMHNSWTK-UHFFFAOYSA-N
CAS Number
CAS 146670-40-8
PubChem Compound ID
127019
PubChem Substance ID
10241697, 14877932, 29306421, 50320075, 57342004, 99437690, 103338419, 103941444, 104364929, 129978712, 135082635, 135651069, 137220333, 140059727, 162249083, 163125597, 204359784, 223717766, 228883789, 241376448, 249617869, 252157269
Target and Pathway
Target(s) Retinoic acid receptor RXR-gamma Target Info Modulator [530188]
KEGG Pathway PPAR signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Small cell lung cancer
Non-small cell lung cancer
Pathway Interaction Database Regulation of Androgen receptor activity
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
a6b1 and a6b4 Integrin signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Adipogenesis
Nuclear Receptors
References
Ref 539850(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2809).
Ref 545989Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005745)
Ref 530188Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology. ChemMedChem. 2009 Jul;4(7):1143-52.

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