Drug Information

Drug General Information
Drug ID
D01JGG
Former ID
DNCL001877
Drug Name
Sodelglitazar
Drug Type
Small molecular drug
Indication Hyperlipidaemia [ICD9: 272.0-272.4; ICD10:E78] Discontinued in Phase 2 [547644]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C23H21F4NO3S2
Canonical SMILES
CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=C(C=C(C=C3)C(F)(F)F)F)C<br />)OC(C)(C)C(=O)O
InChI
1S/C23H21F4NO3S2/c1-12-9-15(6-8-18(12)31-22(3,4)21(29)30)32-11-19-13(2)28-20(33-19)16-7-5-14(10-17(16)24)23(25,26)27/h5-10H,11H2,1-4H3,(H,29,30)
InChIKey
ZUGQWAYOWCBWGM-UHFFFAOYSA-N
CAS Number
CAS 447406-78-2
PubChem Compound ID
9805950
PubChem Substance ID
14762084, 24113736, 44841945, 47208298, 80093574, 126680371, 135207369, 137263940, 139300800, 160681857, 198934584, 223670448, 223864827, 230713277, 241083005, 246356691
Target and Pathway
Target(s) Peroxisome proliferator activated receptor gamma Target Info Agonist [531487]
Peroxisome proliferator activated receptor alpha Target Info Agonist [531487]
Peroxisomeproliferator activated receptor delta Target Info Agonist [531487]
KEGG Pathway PPAR signaling pathway
AMPK signaling pathway
Osteoclast differentiation
Huntington's disease
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancerhsa03320:PPAR signaling pathway
cAMP signaling pathway
Adipocytokine signaling pathway
Glucagon signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis Chsa03320:PPAR signaling pathway
Wnt signaling pathway
Acute myeloid leukemia
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway CCKR signaling map STP00057:Wnt signaling pathway
Pathway Interaction Database Noncanonical Wnt signaling pathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Signaling events mediated by HDAC Class I
RXR and RAR heterodimerization with other nuclear receptor
Regulation of retinoblastoma proteinrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptorps1pathway:Presenilin action in Notch and Wnt signaling
Reactome PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathwayR-HSA-1368082:RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian ClockR-HSA-200425:Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
WikiPathways Wnt Signaling Pathway Netpath
Nuclear Receptors in Lipid Metabolism and Toxicity
Differentiation of white and brown adipocyte
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
Adipogenesis
SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
PPAR Alpha Pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Circadian Clock
Nuclear ReceptorsWP399:Wnt Signaling Pathway and Pluripotency
NRF2 pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Nuclear Receptors
References
Ref 547644Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018093)
Ref 531487Docking and molecular dynamics simulations of peroxisome proliferator activated receptors interacting with pan agonist sodelglitazar. Protein Pept Lett. 2011 Oct;18(10):1021-7.

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