Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M3JI
|
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| Former ID |
DIB003551
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| Drug Name |
SM-19712
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| Drug Type |
Small molecular drug
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| Company |
Sumitomo Pharmaceuticals Co Ltd
|
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| Structure |
|
Download2D MOL |
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| Formula |
C18H14ClN5NaO3S+
|
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| InChI |
InChI=1S/C18H14ClN5O3S.Na/c1-12-16(11-20)17(24(22-12)14-5-3-2-4-6-14)21-18(25)23-28(26,27)15-9-7-13(19)8-10-15;/h2-10H,1H3,(H2,21,23,25);/q;+1
|
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| InChIKey |
XJBBHNFWWJTEGW-UHFFFAOYSA-N
|
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| CAS Number |
CAS 194542-56-8
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Endothelin converting enzyme | Target Info | Inhibitor | [525891], [531869] | |
| References | |||||
| Ref 540736 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5272). | ||||
| Ref 547354 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015442) | ||||
| Ref 525891 | Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. Jpn J Pharmacol. 2000 Sep;84(1):16-24. | ||||
| Ref 531869 | The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Life Sci. 2012 Oct 15;91(13-14):743-8. | ||||
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