Drug General Information
Drug ID	D0LE7P
Former ID	DIB014198
Drug Name	SDZ-GLC-756
Drug Type	Small molecular drug
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Discontinued in Phase 1	[546521]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C20H24N2OS
Canonical SMILES	N1([C@H]2[C@@H](Cc3c(C2)cccc3O)C[C@H](C1)CSc1ncccc1)C
CAS Number	CAS 149328-94-9
PubChem Compound ID	9840900
Target and Pathway
Target(s)	Dopamine D1 receptor	Target Info	Modulator	[534322]
	D(2) dopamine receptor	Target Info	Modulator	[534322]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Morphine addiction
	Alcoholismhsa04015:Rap1 signaling pathway
	Alcoholism
PANTHER Pathway	Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 546521	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008736)
Ref 534322	SDZ GLC 756, a novel octahydrobenzo[g]quinoline derivative exerts opposing effects on dopamine D1 and D2 receptors. J Neural Transm. 1996;103(1-2):17-30.

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